Article
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Nature - 29 Jul 2010
Marcheva Biliana, Ramsey Kathryn Moynihan, Buhr Ethan D, Kobayashi Yumiko, Su Hong, Ko Caroline H, Ivanova Ganka, Omura Chiaki, Mo Shelley, Vitaterna Martha H, Lopez James P, Philipson Louis H, Bradfield Christopher A, Crosby Seth D, JeBailey Lellean, Wang Xiaozhong, Takahashi Joseph S, Bass Joseph
Abstract excerpt
The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism across the day and night. During periods of feeding, pancreatic islets secrete insulin to maintain glucose homeostasis, and although rhythmic control of insulin release is recognized to be dysregulated in humans with diabetes, it is not known how the circadian clock may affect...
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