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Article

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.

Diabetes - 1 Dec 2016

Thomsen Soren K, Ceroni Alessandro, van de Bunt Martijn, Burrows Carla, Barrett Amy, Scharfmann Raphael, Ebner Daniel, McCarthy Mark I, Gloyn Anna L

Abstract excerpt

Most genetic association signals for type 2 diabetes risk are located in noncoding regions of the genome, hindering translation into molecular mechanisms. Physiological studies have shown a majority of disease-associated variants to exert their effects through pancreatic islet dysfunction. Systematically characterizing the role of regional transcripts in β-cell function could identify the underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27554474
DOI: 10.2337/db16-0361
PMCID: PMC5402869

Genes

ARL15
ZMIZ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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