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Article

Genetic Drivers of Pancreatic Islet Function.

Genetics - 1 May 2018

Keller Mark P, Gatti Daniel M, Schueler Kathryn L, Rabaglia Mary E, Stapleton Donnie S, Simecek Petr, Vincent Matthew, Allen Sadie, Broman Aimee Teo, Bacher Rhonda, Kendziorski Christina, Broman Karl W, Yandell Brian S, Churchill Gary A, Attie Alan D

Abstract excerpt

The majority of gene loci that have been associated with type 2 diabetes play a role in pancreatic islet function. To evaluate the role of islet gene expression in the etiology of diabetes, we sensitized a genetically diverse mouse population with a Western diet high in fat (45% kcal) and sucrose (34%) and carried out genome-wide association mapping of diabetes-related phenotypes. We quantified mRNA abundance in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29567659
DOI: 10.1534/genetics.118.300864
PMCID: PMC5937189

Genes

PDX1
SAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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