Article
From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes.
Annual review of genetics - 1 Nov 2025
Kursawe Romy, Bandesh Khushdeep, Krishnan Sai Nivedita, Liu Kevin S, Bhuiyan Redwan M, Stitzel Michael L
Abstract excerpt
Type 2 diabetes (T2D) is a complex genetic disease with substantial environmental inputs leading to glucose homeostasis defects. Insulin production is central to proper glucose control, and islet cell dysfunction and death lie at the nexus of T2D genetics and pathophysiology. Comprehensive identification of genes and pathways contributing to these processes is essential for mechanistic understanding and...
Read the complete abstract on PubMedTopics
- Diabetes Mellitus, Type 2
- Animals
- Humans
- Mice
- Islets of Langerhans
- Genetic Predisposition to Disease