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Article

Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics.

Nature reviews. Endocrinology - 1 Apr 2020

Krentz Nicole A J, Gloyn Anna L

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has both genetic and environmental risk factors, resulting in impaired glucose homeostasis. Genome-wide association studies (GWAS) have identified over 400 genetic signals that are associated with altered risk of T2DM. Human physiology and epigenomic data support a central role for the pancreatic islet in the pathogenesis of...

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Diabetes Mellitus, Type 2
Epigenetics and DNA Methylation
Genetic Predisposition to Disease
Genetics and Neurodevelopmental Disorders
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Secreting Cells

Models, Biological

Pancreatic function and diabetes

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PMID: 32099086
DOI: 10.1038/s41574-020-0325-0

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