Article
Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.
The EMBO journal - 12 May 2015
Jia Shiqi, Ivanov Andranik, Blasevic Dinko, Müller Thomas, Purfürst Bettina, Sun Wei, Chen Wei, Poy Matthew N, Rajewsky Nikolaus, Birchmeier Carmen
Abstract excerpt
Key transcription factors control the gene expression program in mature pancreatic β-cells, but their integration into regulatory networks is little understood. Here, we show that Insm1, Neurod1 and Foxa2 directly interact and together bind regulatory sequences in the genome of mature pancreatic β-cells. We used Insm1 ablation in mature β-cells in mice and found pronounced deficits in insulin secretion and gene...
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