Article

High-throughput affinity measurements of direct interactions between activation domains and co-activators

2024-08-20

Abstract excerpt

Sequence-specific activation by transcription factors is essential for gene regulation 1,2 . Key to this are activation domains, which often fall within disordered regions of transcription factors 3,4 and recruit co-activators to initiate transcription 5 . These interactions are difficult to characterize via most experimental techniques because they are typically weak and transient 6,7 . Consequently, we know...

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Literature Corpus work: ec864813-0f3a-5f25-aa0d-99593a911699
DOI: 10.1101/2024.08.19.608698

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