μDamID: a microfluidic approach for imaging and sequencing protein-DNA interactions in single cells

Abstract excerpt

Genome regulation depends on carefully programmed protein-DNA interactions that maintain or alter gene expression states, often by influencing chromatin organization. Most studies of these interactions to date have relied on bulk methods, which in many systems cannot capture the dynamic single-cell nature of these interactions as they modulate cell states. One method allowing for sensitive single-cell mapping of p...

Topics

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• Alleles
• Chromatin
• DNA
• High-Throughput Screening Assays
• In Situ Hybridization, Fluorescence
• RNA
• Transcription, Genetic

Identifiers and source

Literature Corpus work

f3b04780-06e1-59ff-946f-22c552f755a0

DOI

10.1101/706903