Article

Single-Cell Protein Interactomes by the Proximity Network Assay

2025-06-24

Abstract excerpt

Cellular function depends on dynamic interactions and nanoscale spatial organisation of proteins. While transcriptomic and proteomic methods have enabled single-cell profiling, scalable technologies allowing high-resolution analysis of protein interactions at omics-scale are lacking. Here we present the Proximity Network Assay (PNA), a DNA-based method for constructing three-dimensional nanoscale maps of 155 prote...

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Literature Corpus work: faef9306-a165-553a-bf3f-b7605445ac34
DOI: 10.1101/2025.06.19.660329

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