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High-Throughput Affinity Measurements of Transcription Factor and DNA Mutations Reveal Affinity and Specificity Determinants.

Cell systems - 17 Feb 2021

Aditham Arjun K, Markin Craig J, Mokhtari Daniel A, DelRosso Nicole, Fordyce Polly M

Abstract excerpt

Transcription factors (TFs) bind regulatory DNA to control gene expression, and mutations to either TFs or DNA can alter binding affinities to rewire regulatory networks and drive phenotypic variation. While studies have profiled energetic effects of DNA mutations extensively, we lack similar information for TF variants. Here, we present STAMMP (simultaneous transcription factor affinity measurements via...

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PMID: 33340452
DOI: 10.1016/j.cels.2020.11.012

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Source receipt: pubmed, retrieved 7 Sept 2026.

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