Article

Customizable high-throughput platform for profiling cofactor recruitment to DNA to characterize cis-regulatory elements and screen non-coding single-nucleotide polymorphisms

2020-04-22

Abstract excerpt

Determining how DNA variants affect the binding of regulatory complexes to cis-regulatory elements (CREs) and non-coding single-nucleotide polymorphisms (ncSNPs) is a challenge in genomics. To address this challenge, we have developed CASCADE ( C omprehensive AS sessment of C omplex A ssembly at D NA E lements), which is a protein-binding microarray (PBM)-based approach that allows for the high-throughput pr...

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Literature Corpus work: 0af5dcd4-c027-592f-9591-c4c000ffc17d
DOI: 10.1101/2020.04.21.053710

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