Article

Design principles of acidic transcriptional activation domains

2020-10-28

Abstract excerpt

Acidic activation domains are intrinsically disordered regions of transcription factors that bind coactivators. The intrinsic disorder and low conservation of activation domains have made it difficult to identify general rules governing their function. To address this problem, we designed thousands of variants in seven acidic activation domains and measured their activities with a new high-throughput assay in huma...

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Literature Corpus work: 668f4d94-8d81-5ee3-af16-315defafc193
DOI: 10.1101/2020.10.28.359026

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