Article

Single-molecule chromatin configurations link transcription factor binding to expression in human cells

2024-02-04

Abstract excerpt

The binding of multiple transcription factors (TFs) to genomic enhancers activates gene expression in mammalian cells. However, the molecular details that link enhancer sequence to TF binding, promoter state, and gene expression levels remain opaque. We applied single-molecule footprinting (SMF) to measure the simultaneous occupancy of TFs, nucleosomes, and components of the transcription machinery on engineered e...

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Literature Corpus work: bb27783a-d60a-5f31-afbd-ed9e1a159842
DOI: 10.1101/2024.02.02.578660

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