Article

Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction

2021-11-04

Abstract excerpt

The phenotypic efficacy of somatic copy number alterations (SCNAs) stems from their incidence per base pair of the genome, which is orders of magnitudes greater than that of point mutations. One mitotic event stands out in its potential to significantly change a cell’s SCNA burden–a chromosome missegregation. We present a general deterministic framework for modeling chromosome missegregations and use it to evaluat...

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Literature Corpus work: ec7b94a1-12d2-5239-b80d-a0596a6a6eff
DOI: 10.1101/2021.11.03.466486

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