Article

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

2024-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Whole-genome doubling (WGD) is a critical driver of tumor development and is linked to drug resistance and metastasis in solid malignancies. Here, we demonstrate that WGD is an ongoing mutational process in tumor evolution. Using single-cell whole-genome sequencing, we measured and modeled how WGD events are distributed across cellular populations within tumors and associated WGD dynamics with p...

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Literature Corpus work: f7f88ae2-83be-50d4-9843-7846671578c0
DOI: 10.1101/2024.07.11.602772

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