Article
CINner: Modeling and simulation of chromosomal instability in cancer at single-cell resolution.
PLoS computational biology - 1 Apr 2025
Dinh Khanh N, Vázquez-García Ignacio, Chan Andrew, Malhotra Rhea, Weiner Adam, McPherson Andrew W, Tavaré Simon
Abstract excerpt
Cancer development is characterized by chromosomal instability, manifesting in frequent occurrences of different genomic alteration mechanisms ranging in extent and impact. Mathematical modeling can help evaluate the role of each mutational process during tumor progression, however existing frameworks can only capture certain aspects of chromosomal instability (CIN). We present CINner, a mathematical framework...
Read the complete abstract on PubMedTopics
- Chromosomal Instability
- Humans
- Neoplasms
- Single-Cell Analysis
- Models, Genetic
- DNA Copy Number Variations