Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Markov chain for numerical chromosomal instability in clonally expanding populations.

PLoS computational biology - 1 Sept 2018

Elizalde Sergi, Laughney Ashley M, Bakhoum Samuel F

Abstract excerpt

Cancer cells frequently undergo chromosome missegregation events during mitosis, whereby the copies of a given chromosome are not distributed evenly among the two daughter cells, thus creating cells with heterogeneous karyotypes. A stochastic model tracing cellular karyotypes derived from clonal populations over hundreds of generations was recently developed and experimentally validated, and it was capable of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Instability
Share to Chromosomes
Share to Karyotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Markov Chains

Share to Mitosis

Share to Models, Statistical

Share to Probability

Share to Stochastic Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 30204765
DOI: 10.1371/journal.pcbi.1006447
PMCID: PMC6150543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Markov chain for numerical chromosomal instability in clonally expanding populations.PMID 30204765Read ↗

Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinctionSemantic proximity Read ↗

Cell-cycle dependent DNA repair and replication unifies patterns of chromosome instabilitySemantic proximity Read ↗

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues.Semantic proximity Read ↗

The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approachSemantic proximity Read ↗

The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling.Semantic proximity Read ↗

Predicting CIN rates from single-cell whole genome sequencing data using an <i>in silico</i> modelSemantic proximity Read ↗

Lineage tracing in human tissues.Semantic proximity Read ↗

Genetic instability and clonal expansion.Semantic proximity Read ↗

Immortality of cancers: a consequence of inherent karyotypic variations and selections for autonomy.Semantic proximity Read ↗

On the karyotypic origin and evolution of cancer cells.Semantic proximity Read ↗

Tracking Karyotype Changes in Treatment-Induced Drug-Resistant Evolution.Semantic proximity Read ↗

Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.