Spatial population structure can reverse the dependence of mutant burden on the death-to-birth ratio of cells

Abstract excerpt

Expanding cell populations, including bacterial colonies and tumors, continuously accumulate mutations as they grow. Yet how mutant burden depends on the cellular death-to-birth ratio in spatially structured populations has not been addressed, despite clinical studies associating higher tumor turnover with both better and worse patient outcomes across cancers. This question is especially relevant for deleterious m...

Topics

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• Algorithms
• Bacteria
• Computer Simulation
• Evolution, Molecular
• Genetic Fitness
• Models, Genetic
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

ee9f8cfe-c878-5702-acce-6f96a82f4b4e

DOI

10.1101/2025.11.17.688895