Article
Perturbation-Driven Entropy as a Source of Cancer Cell Heterogeneity.
Trends in cancer - 1 Jun 2020
Nijman Sebastian M B
Abstract excerpt
Intratumor heterogeneity is a key hallmark of cancer that contributes to progression and therapeutic resistance. Phenotypic heterogeneity is in part caused by Darwinian selection of subclones that arise by random (epi)genetic aberrations. In addition, cancer cells are endowed with increased cellular plasticity compared with their normal counterparts, further adding to their heterogeneous behavior. However, the...
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