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Article

Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells.

Cancer metastasis reviews - 1 Dec 2013

Huang Sui

Abstract excerpt

Genetic instability is invoked in explaining the cell phenotype changes that take place during cancer progression. However, the coexistence of a vast diversity of distinct clones, most prominently visible in the form of non-clonal chromosomal aberrations, suggests that Darwinian selection of mutant cells is not operating at maximal efficacy. Conversely, non-genetic instability of cancer cells must also be...

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PMID: 23640024
DOI: 10.1007/s10555-013-9435-7

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