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Population dynamics is a cancer driver.

Carcinogenesis - 30 Dec 2024

Dos Santos Oliveira Mariana, de C Griebeler Marcelo, Henz Bernardo, Dos Santos Filipe Ferreira, Guardia Gabriela D A, Conceição Helena B, Galante Pedro A F, Minussi Darlan C, Oliveira Manuel M, Lenz Guido

Abstract excerpt

Most tissues are continuously renovated through the division of stem cells and the death of old or damaged cells, which is known as the cell turnover rate (CTOR). Despite being in a steady state, tissues have different population dynamics thus producing diverse clonality levels. Here, we propose and test that cell population dynamics can be a cancer driver. We employed the evolutionary software esiCancer to show...

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PMID: 38842162
DOI: 10.1093/carcin/bgae038

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