Article

Characterization of an RNA binding protein interactome reveals the targetable post-transcriptional landscape of MYC-amplified medulloblastoma

2022-03-28

Abstract excerpt

<title>Abstract</title> <p>Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. <italic>MYC</italic> amplification is an independent poor prognostic factor in G3 MB, however, therapeutic targeting of the MYC pathway remains limited and alternative therapies for G3 MB are urgently needed. Here we show that the RNA-binding...

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Literature Corpus work: ec66ff72-4654-59e6-8f12-de2d67ec2d21
DOI: 10.21203/rs.3.rs-549885/v1

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