Article

Knockdown of Musashi-1 enhances chemotherapeutic sensitivity and apoptosis in Group 3/4 medulloblastomas cells

2022-07-06

Abstract excerpt

Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a paucity of biomarkers for these subtypes of MBs. The RNA-binding protein Musashi-1 ( MSI1 ) is a neural stem cell marker, characterized as a gene translation regulator and associated with high oncogenicity in several human cancers. In this study, we investigate...

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Literature Corpus work: 23e3981c-bfe7-5e7d-a941-ed2abe6d0e10
DOI: 10.21203/rs.3.rs-1800310/v1

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