Article

In-depth Inference of Transcriptional Regulatory Networks Identifies NPM1 as a Druggable Master Regulator in Medulloblastoma

2023-11-06

Abstract excerpt

<title>Abstract</title> <p>Medulloblastoma (MB) is a highly malignant embryonic brain tumor with distinct cytogenetic heterogeneity in children. Despite elucidating divergent regulatory underpinnings in MB molecular subtypes, the hidden oncogenic signaling drivers with minimal differential expression remain obscure. Here, we leveraged two bulk RNA-seq datasets involving 1055 patients to construct pediatric MB spe...

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Literature Corpus work: 5baaea6b-44fa-50cc-a7c7-66514a83dff6
DOI: 10.21203/rs.3.rs-3490040/v1

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