Article

The <i>EIF4EBP1</i> gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastoma

2024-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Medulloblastoma (MB) is the most common malignant brain tumor in childhood and is stratified into four molecular groups ‒ WNT, SHH, Group 3 and Group 4. Group 3 MB patients exhibit the poorest prognosis, with a 5-year overall survival of <60%, followed by Group 4 MB patients. Apart from MYC amplification in a subset of Group 3 MBs, the molecular pathomechanisms driving aggressiveness of these t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7ccacc1-0c35-596e-8815-6de1c49dafe3
DOI: 10.1101/2024.03.06.583558

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The <i>EIF4EBP1</i> gene encoding 4EBP1 is transcriptionally upregulated by MYC and linked to shorter survival in medulloblastomaDOI 10.1101/2024.03.06.583558Read

<i>EIF4EBP1</i> is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastomaSemantic proximity Read

Effective inhibition of MYC-amplified Group 3 medulloblastoma through targeting translation machinery eIF4F complexSemantic proximity Read

Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibitionSemantic proximity Read

Characterization of an RNA binding protein interactome reveals the targetable post-transcriptional landscape of MYC-amplified medulloblastomaSemantic proximity Read

Signaling pathway and molecular subgroups of medulloblastoma.Semantic proximity Read

An Immune Microenvironment-Associated Gene Signature Predicts Outcomes and Therapeutic Response in Pediatric MedulloblastomaSemantic proximity Read

Signaling pathway deregulation and molecular alterations across pediatric medulloblastomas.Semantic proximity Read

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cellsSemantic proximity Read

MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastomaSemantic proximity Read

Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in NeuroblastomaSemantic proximity Read

PRMT5 as an Epigenetic Target for Group 3 (MYC-driven) MedulloblastomaSemantic proximity Read

Loss of nuclear envelope phosphatase CTDNEP1 drives aggressive medulloblastoma by triggering MYC amplification and genomic instabilitySemantic proximity Read