Article

Human stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscape

2025-12-08

Abstract excerpt

Medulloblastoma (MB) is one of the most prevalent malignant brain tumors in children, with tremendous cognitive and neuroendocrine disability among survivors. Group 3 MB (G3MB) has poor overall survival at <50%, high frequencies of metastases, and no targeted therapies. Amplification of MYC and activation of TGFβ signaling occur frequently in G3MB. Many tumors have no reported mutations, suggesting epigenetic dri...

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Literature Corpus work: 2ab764d5-f0af-5e01-8592-0c8e09eccd19
DOI: 10.64898/2025.12.06.689939

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