Article

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

2018-05-14

Abstract excerpt

<h4>SUMMARY</h4> The MUSASHI family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We found that the small molecule Ro 08–2750 (Ro) directly binds to MSI2 and competes for its RNA binding in biochemical assays. Ro treatment in mouse and human myeloid leukemia cells resulted in an increase in differentiation and apoptosis, inhibition of known MSI-...

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Literature Corpus work: b35080d1-7446-5c48-829f-45c8e71e574b
DOI: 10.1101/321174

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