Article

PRMT5 as an Epigenetic Target for Group 3 (MYC-driven) Medulloblastoma

2026-04-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Group 3 (MYC-driven) medulloblastoma (MB) is a highly aggressive brain tumor with poor-prognosis and limited treatment options. We previously identified protein-arginine methyltransferase-5 (PRMT5) as a promising target in Group 3 MB with its control on MYC protein stability. In this follow up study, we further mechanistically investigated PRMT5 control on MYC transcription...

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Literature Corpus work: 691acd47-b333-5621-b88f-6850665a4099
DOI: 10.64898/2026.04.09.717536

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