Article

Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells

2022-10-21

Abstract excerpt

In metazoans, both transcription initiation and the escape of RNA polymerase (RNAP) from promoter-proximal pausing are key rate-limiting steps in gene expression. These processes play out at physically proximal sites on the DNA template and appear to influence one another through steric interactions, leading to a complex dynamic equilibrium in RNAP occupancy of the ~100 bp immediately downstream of the transcripti...

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Literature Corpus work: ec09f9c3-d517-58f3-a924-82b9603a63c6
DOI: 10.1101/2022.10.19.512929

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