Article

Model-based characterization of the equilibrium dynamics of transcription initiation and promoter-proximal pausing in human cells

2022-12-06

Abstract excerpt

<title>Abstract</title> <p>In metazoans, both transcription initiation and the escape of RNA polymerase (RNAP) from promoter-proximal pausing are key rate-limiting steps in gene expression. These processes play out at physically proximal sites on the DNA template and appear to influence one another through steric interactions, leading to a complex dynamic equilibrium in RNAP occupancy of the ∼100 bp immediately d...

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Literature Corpus work: 6690c015-6271-5f03-8413-c69941a7bfd8
DOI: 10.21203/rs.3.rs-2247832/v1

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