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Article

STL-seq reveals pause-release and termination kinetics for promoter-proximal paused RNA polymerase II transcripts.

Molecular cell - 4 Nov 2021

Zimmer Joshua T, Rosa-Mercado Nicolle A, Canzio Daniele, Steitz Joan A, Simon Matthew D

Abstract excerpt

Despite the critical regulatory function of promoter-proximal pausing, the influence of pausing kinetics on transcriptional control remains an active area of investigation. Here, we present Start-TimeLapse-seq (STL-seq), a method that captures the genome-wide kinetics of short, capped RNA turnover and reveals principles of regulation at the pause site. By measuring the rates of release into elongation and...

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Identifiers

PMID: 34520723
DOI: 10.1016/j.molcel.2021.08.019
PMCID: PMC9020433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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