Article

Timing polymerase pausing with TV-PRO-seq: dissecting the interplay of pausing duration and location, and gene expression

2018-11-04

Abstract excerpt

Transcription of many genes in metazoans is subject to polymerase pausing, which is the transient stop of transcriptionally-engaged polymerases. This is known to mainly occur in promoter proximal regions but it is not well understood. In particular, a genome-wide measurement of pausing times at high resolution has been lacking. We present here the time-variant precision nuclear run-on and sequencing (TV-PRO-seq) a...

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Literature Corpus work: 3c76aa5c-3679-5648-9529-66c40ac677c8
DOI: 10.1101/461442

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