Article

LIET Model: Capturing the kinetics of RNA polymerase from loading to termination

2024-10-03

Abstract excerpt

Transcription by RNA polymerases is an exquisitely regulated step of the central dogma. Transcription is the primary determinant of cell-state, and most cellular perturbations impact transcription by altering polymerase activity. Thus, detecting changes in polymerase activity yields insight into most cellular processes. Nascent run-on sequencing provides a direct readout of polymerase activity, but no tools exist...

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Literature Corpus work: 20e0d1c7-0f37-5610-b156-9a7ab2e1b48f
DOI: 10.1101/2024.10.03.616401

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