Article

Temporal resolution of global gene expression and DNA methylation changes in the final phases of reprogramming towards induced pluripotency

2019-02-13

Abstract excerpt

The generation of induced pluripotent stem cells (iPSCs) involves activation of the endogenous pluripotency circuitry and global DNA demethylation late in reprogramming, but temporal resolution of these events using existing markers is insufficient. Here, we generated murine transgenic lines harboring dual fluorescent reporters reflecting cell-state specific expression of the master pluripotency factor Oct4 and t...

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Literature Corpus work: ebdc96d6-4a55-5ea3-b32e-5fc6f601c674
DOI: 10.1101/547646

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