Article
Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion.
Molecular cell - 28 Mar 2013
Piccolo Francesco M, Bagci Hakan, Brown Karen E, Landeira David, Soza-Ried Jorge, Feytout Amelie, Mooijman Dylan, Hajkova Petra, Leitch Harry G, Tada Takashi, Kriaucionis Skirmantas, Dawlaty Meelad M, Jaenisch Rudolf, Merkenschlager Matthias, Fisher Amanda G
Abstract excerpt
Genomic imprinting directs the allele-specific marking and expression of loci according to their parental origin. Differential DNA methylation at imprinted control regions (ICRs) is established in gametes and, although largely preserved through development, can be experimentally reset by fusing somatic cells with embryonic germ cell (EGC) lines. Here, we show that the Ten-Eleven Translocation proteins Tet1 and...
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