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Article

Analysis of endogenous Oct4 activation during induced pluripotent stem cell reprogramming using an inducible Oct4 lineage label.

Stem cells (Dayton, Ohio) - 1 Nov 2012

Greder Lucas V, Gupta Sandeep, Li Shunan, Abedin Md Joynal, Sajini Abdulrahim, Segal Yoav, Slack Jonathan M W, Dutton James R

Abstract excerpt

The activation of endogenous Oct4 transcription is a key step in the reprogramming of somatic cells into induced pluripotent stem (iPS) cells but until now it has been difficult to analyze this critical event in the reprogramming process. We have generated a transgenic mouse that expresses the tamoxifen-inducible Cre recombinase MerCreMer under the control of the endogenous Oct4 locus, enabling lineage tracing of...

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Identifiers

PMID: 22948941
DOI: 10.1002/stem.1216
PMCID: PMC3626284

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