Article

WT1 splice isoforms configure lineage bias during formative pluripotency

2026-04-08

Abstract excerpt

<h4>ABSTRACT</h4> When and how lineage competence first emerges in the epiblast remains a central question in mammalian development. During the transition from naïve to formative pluripotency, epiblast cells acquire responsiveness to lineage-inducing cues, yet whether transcriptional heterogeneity in this window reflects a regulated programme of lineage emergence or stochastic variation, and which molecular regul...

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Literature Corpus work: 2c854319-76d5-5be1-a2d3-4fbea1ab6585
DOI: 10.64898/2026.04.06.713568

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