Article

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

2021-04-07

Abstract excerpt

Severe COVID-19 is characterised by immunopathology and epithelial injury. Proteomic studies have identified circulating proteins that are biomarkers of severe COVID-19, but cannot distinguish correlation from causation. To address this, we performed Mendelian randomisation (MR) to identify proteins that mediate severe COVID-19. Using protein quantitative trait loci (pQTL) data from the SCALLOP consortium, involvi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eaf92597-da3c-58c9-a31d-233be26575a7
DOI: 10.1101/2021.04.01.21254789

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19DOI 10.1101/2021.04.01.21254789Read

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevanceSemantic proximity Read

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevanceSemantic proximity Read

Transcriptome‐wide summary data‐based Mendelian randomization analysis reveals 38 novel genes associated with severe COVID‐19Semantic proximity Read

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.Semantic proximity Read

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severitySemantic proximity Read

Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVIDSemantic proximity Read

The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses.Semantic proximity Read

Common and rare variant analyses combined with single-cell multiomics reveal cell-type-specific molecular mechanisms of COVID-19 severitySemantic proximity Read

The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature.Semantic proximity Read

Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity.Semantic proximity Read

Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19.Semantic proximity Read

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infectionSemantic proximity Read