Article
The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses.
Frontiers in immunology - 1 Jan 2022
Kuijpers Yunus, Chu Xiaojing, Jaeger Martin, Moorlag Simone J C F M, Koeken Valerie A C M, Zhang Bowen, de Nooijer Aline, Grondman Inge, Gupta Manoj Kumar, Janssen Nico, Mourits Vera P, de Bree L Charlotte J, de Mast Quirijn, van de Veerdonk Frank L, Joosten Leo A B, Li Yang, Netea Mihai G, Xu Cheng-Jian
Abstract excerpt
Recent genome-wide association studies (GWASs) of COVID-19 patients of European ancestry have identified genetic loci significantly associated with disease severity. Here, we employed the detailed clinical, immunological and multi-omics dataset of the Human Functional Genomics Project (HFGP) to explore the physiological significance of the host genetic variants that influence susceptibility to severe COVID-19. A...
Topics
- COVID-19
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Immunity
- von Willebrand Factor