Article
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Human genetics - 1 Jan 2022
Fallerini Chiara, Picchiotti Nicola, Baldassarri Margherita, Zguro Kristina, Daga Sergio, Fava Francesca, Benetti Elisa, Amitrano Sara, Bruttini Mirella, Palmieri Maria, Croci Susanna, Lista Mirjam, Beligni Giada, Valentino Floriana, Meloni Ilaria, Tanfoni Marco, Minnai Francesca, Colombo Francesca, Cabri Enrico, Fratelli Maddalena, Gabbi Chiara, Mantovani Stefania, Frullanti Elisa, Gori Marco, Crawley Francis P, Butler-Laporte Guillaume, Richards Brent, Zeberg Hugo, Lipcsey Miklos, Hultström Michael, Ludwig Kerstin U, Schulte Eva C, Pairo-Castineira Erola, Baillie John Kenneth, Schmidt Axel, Frithiof Robert, Mari Francesca, Renieri Alessandra, Furini Simone
Abstract excerpt
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the...
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