Article

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infection

2025-06-30

Abstract excerpt

The impact of genotype on gene expression can depend on both cellular and organismal context. Here, we leverage an extensive blood atlas of genotyped patients with varying severity of infection produced by the COVID-19 Multi-omics Blood ATlas (COMBAT) Consortium to study the role of genetic regulation on gene expression in a context-specific manner. We analyzed single-cell transcriptomic and genome-wide genetic da...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a819dabf-be86-5520-aec2-9353ae41f1b4
DOI: 10.1101/2025.06.30.25330463

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infectionDOI 10.1101/2025.06.30.25330463Read

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.Semantic proximity Read

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.Semantic proximity Read

Deciphering the genetic control of immune cell function at single-cell resolution: Disease-Specific Cis-eQTLs analysis of COVID-19.Semantic proximity Read

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.Semantic proximity Read

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.Semantic proximity Read

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell typesSemantic proximity Read

Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severitySemantic proximity Read

Genetic variants associated with cell-type-specific intra-individual gene expression variability reveal new mechanisms of genome regulationSemantic proximity Read

Transcriptome‐wide summary data‐based Mendelian randomization analysis reveals 38 novel genes associated with severe COVID‐19Semantic proximity Read

Whole Genome DNA and RNA Sequencing of Whole Blood Elucidates the Genetic Architecture of Gene Expression Underlying a Wide Range of DiseasesSemantic proximity Read

Functional Inference of Gene Regulation using Single-Cell Multi-OmicsSemantic proximity Read

Impact of rare and common genetic variation on cell type-specific gene expression in human bloodSemantic proximity Read