Article

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

2021-03-17

Abstract excerpt

The virus SARS-CoV-2 can exploit biological vulnerabilities in susceptible hosts that predispose to development of severe COVID-19. Previous reports have identified several host proteins related to the interferon response (e.g. OAS1), interleukin-6 signalling (IL-6R), and the coagulation cascade (linked via ABO) that were associated with risk of COVID-19. In the present study, we performed proteome-wide genetic co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2ddcfb7-e21e-53c0-9530-c2310a300f64
DOI: 10.1101/2021.03.15.21253625

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevanceDOI 10.1101/2021.03.15.21253625Read

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevanceSemantic proximity Read

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19Semantic proximity Read

Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19.Semantic proximity Read

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalizationSemantic proximity Read

The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review.Semantic proximity Read

Computational Network Analysis of Host Genetic Risk Variants of Severe COVID-19Semantic proximity Read

The molecular biology of SARS-CoV-2 pathogenesis, host genetics and associated interactions in infectionSemantic proximity Read

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization.Semantic proximity Read

Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19Semantic proximity Read

The seven enigmas of SARS-CoV-2: From the past to the futureSemantic proximity Read

Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.Semantic proximity Read

Immune interaction map of human SARS-CoV-2 target proteins: implications for therapeutic avenuesSemantic proximity Read