Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

13 Aug 2021

Abstract excerpt

Background: The virus SARS-CoV-2 can exploit biological vulnerabilities (e.g. host proteins) in susceptible hosts that predispose to the development of severe COVID-19. Methods: To identify host proteins that may contribute to the risk of severe COVID-19, we undertook proteome-wide genetic colocalisation tests, and polygenic (pan) and cis-Mendelian randomisation analyses leveraging publicly available protein and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Machine Learning in Bioinformatics
Share to vaccines and immunoinformatics approaches

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34402426
DOI: 10.7554/elife.69719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevancePMID 34402426Read ↗

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevanceSemantic proximity Read ↗

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19Semantic proximity Read ↗

Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19.Semantic proximity Read ↗

The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review.Semantic proximity Read ↗

Multi-Ancestry Mendelian Randomization of Omics Traits Revealing Putative Drug Targets of COVID-19 SeveritySemantic proximity Read ↗

COVID-19: Variant screening, an important step towards precision epidemiologySemantic proximity Read ↗

Multi-ancestry omic Mendelian randomization revealing putative drug targets of COVID-19 severitySemantic proximity Read ↗

Structure, function and variants analysis of the androgen-regulated <i>TMPRSS2</i> , a drug target candidate for COVID-19 infectionSemantic proximity Read ↗

Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity.Semantic proximity Read ↗

Immune interaction map of human SARS-CoV-2 target proteins: implications for therapeutic avenuesSemantic proximity Read ↗

Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomesSemantic proximity Read ↗

Genetic risk factors for death with SARS-CoV-2 from the UK BiobankSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.