Article

Mapping AML heterogeneity – multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses

2023-03-29

Abstract excerpt

Subtyping of acute myeloid leukaemia (AML) is predominantly based on recurrent genetic abnormalities, but recent literature indicates that transcriptomic phenotyping holds immense potential to further refine AML classification. Here we integrated five AML transcriptomic datasets with corresponding genetic information to provide an overview (n=1224) of the transcriptomic AML landscape. Consensus clustering identifi...

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Literature Corpus work: d76692a9-0e5b-5593-a9b9-6bf66e2cda10
DOI: 10.1101/2023.03.29.23287896

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