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Mapping AML heterogeneity - multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses.

Leukemia - 1 Apr 2024

Severens Jeppe F, Karakaslar E Onur, van der Reijden Bert A, Sánchez-López Elena, van den Berg Redmar R, Halkes Constantijn J M, van Balen Peter, Veelken Hendrik, Reinders Marcel J T, Griffioen Marieke, van den Akker Erik B

Abstract excerpt

Subtyping of acute myeloid leukaemia (AML) is predominantly based on recurrent genetic abnormalities, but recent literature indicates that transcriptomic phenotyping holds immense potential to further refine AML classification. Here we integrated five AML transcriptomic datasets with corresponding genetic information to provide an overview (n = 1224) of the transcriptomic AML landscape. Consensus clustering...

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PMID: 38360865
DOI: 10.1038/s41375-024-02137-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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