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Characterization of bone marrow heterogeneity in NK-AML (M4/M5) based on single-cell RNA sequencing

6 Mar 2023

Abstract excerpt

Normal karyotype acute myeloid leukemia (NK-AML) is a heterogeneous hematological malignancy that contains a minor population of self-renewing leukemia stem cells (LSCs), which complicate efforts to achieve long-term survival. We performed single-cell RNA sequencing to profile 39,288 cells from 6 bone marrow (BM) aspirates including 5 NK-AML (M4/M5) patients and 1 healthy donor. The single-cell transcriptome...

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Acute Myeloid Leukemia Research
Cancer Genomics and Diagnostics
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36879313
DOI: 10.1186/s40164-023-00391-5

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