Article

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

2023-12-27

Abstract excerpt

In acute myeloid leukemia (AML), genetic mutations distort hematopoietic differentiation, resulting in the accumulation of leukemic blasts. Yet, it remains unclear how these mutations intersect with cellular origins and whether they converge upon similar differentiation patterns. Single-cell RNA sequencing (scRNA-seq) has enabled high-resolution mapping of the relationship between leukemia and normal cell states,...

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Literature Corpus work: c05b0da6-8c80-5b00-8045-515638ccf100
DOI: 10.1101/2023.12.26.573390

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