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Article

Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia.

Cell stem cell - 3 Jul 2025

Sirenko Maria, Lee Soobeom, Sun Zhengxi, Chaligne Ronan, Loghavi Sanam, Asimomitis Georgios, Brierley Charlotte K, Bernard Elsa, Cai Sheng F, Myers Robert M, Nadorp Bettina, Sango Junya, Lallo Morgan, Levine Max F, Domenico Dylan, Arango Ossa Juan E, Medina-Martinez Juan S, Menghrajani Kamal, Lasry Audrey, Mims Alice S, Desai Helee, Laganson Andrea, Famulare Chris, Patel Minal, Lozanski Gerard, Bolton Kelly L, Viny Aaron D, Roshal Mikhail, Levine Ross L, Papapetrou Eirini P, Stein Eytan M, Landau Dan A, Eisfeld Ann-Kathrin, Aifantis Iannis, Papaemmanuil Elli

Abstract excerpt

Isocitrate dehydrogenase 1/2 (IDH) mutations are early initiating events in acute myeloid leukemia (AML). The complex clonal architecture and cellular heterogeneity in IDH-mutant AML underlies the heterogeneous clinical presentation and outcomes. Integrating single-cell genotyping and transcriptomics, we demonstrate a stem-like and inflammatory phenotype of IDH-mutant AML and identify clone-specific programs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40409258
DOI: 10.1016/j.stem.2025.04.012
PMCID: PMC12857296

Genes

IDH2
NPM1
NRAS
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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