Article
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.
Cell - 7 Mar 2019
van Galen Peter, Hovestadt Volker, Wadsworth Ii Marc H, Hughes Travis K, Griffin Gabriel K, Battaglia Sofia, Verga Julia A, Stephansky Jason, Pastika Timothy J, Lombardi Story Jennifer, Pinkus Geraldine S, Pozdnyakova Olga, Galinsky Ilene, Stone Richard M, Graubert Timothy A, Shalek Alex K, Aster Jon C, Lane Andrew A, Bernstein Bradley E
Abstract excerpt
Acute myeloid leukemia (AML) is a heterogeneous disease that resides within a complex microenvironment, complicating efforts to understand how different cell types contribute to disease progression. We combined single-cell RNA sequencing and genotyping to profile 38,410 cells from 40 bone marrow aspirates, including 16 AML patients and five healthy donors. We then applied a machine learning classifier to...
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