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The cellular state space of AML unveils novel <i>NPM1</i> subtypes with distinct clinical outcomes and immune evasion properties

2025-02-17

Abstract excerpt

Acute myeloid leukemia (AML) is a genetically and cellularly heterogeneous disease. We characterized 120 AMLs using genomic and transcriptomic analyses, including single-cell RNA sequencing. Our results reveal an extensive cellular heterogeneity that distorts the bulk transcriptomic profiles. Selective examination of the transcriptional signatures of >90,000 immature AML cells identified four main clusters, thereb...

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Literature Corpus work
fefe0621-9f46-5665-a7fb-d634cb70d307
DOI
10.1101/2025.02.12.637826
Open publication

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